Engineering T Cells: From Mechanism to Medicine
Journal: Cancer Biology & Therapy
Chimeric antigen receptor (CAR)-T cell therapy has redefined cancer immunotherapy. By re-engineering a patient's own T cells to recognize tumor antigens, CAR-T has delivered deep, durable, and curative responses in B-cell malignancies, including relapsed or refractory leukemias, lymphomas, and multiple myeloma, where conventional therapies had failed. This success has motivated efforts to improve the safety and effi…